We consider the Contrast agent development, Synthetic Chemistry and Radiopharmaceuticals Resource as one of the cornerstones of the ICMIC, as all modalities are augmented by new contrast agents, and imaging probes are necessary for several applications in the research studies of the JHU ICMIC. The chemistry to be performed in this resource center is not modality-specific, but driven by the needs of the investigators. Identification and validation of new targets and development of novel contrast agents directed toward those and other targets will occur in this core resource center through semi-weekly interactions with the leaders of the Research Components and the Developmental Projects, and with key imaging personnel. Those interactions will occur either at formal group meetings, or through our web site that will have an interactive forum. The Contrast agent development, synthetic chemistry and radiopharmaceuticals resource will also interact with the Imaging, Image Analysis and Statistical Analysis Resource from which it will receive feedback regarding the utility of the new imaging agents developed. Iterative feedback between those two core resources will enable optimization of imaging agents for MR, radionuclide and optical applications. Collaborations with leading scientists have been established to ensure that state of the art agents and probes will be made available to the investigators within the JHU ICMIC to enhance and facilitate their research studies. JHU ICMIC investigators will utilize this resource to obtain existing, state-of-the-art contrast agents and imaging probes. A wide array of MR contrast agents and radiopharmaceuticals will be available. To assure the ready availability of routine agents, the SAIRP which is integrated with the JHU ICMIC has recruited one and is in the process of recruiting a second full-time chemist, each of whose mission will be, in part, to provide standard imaging probes. The Medicinal Chemistry Core facility in Oncology, lead by Dr. Saeed Khan, will also serve that purpose as needed.